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Practical Process Research and Development
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Review
"... A must reference on every process chemists (both the novice and the experienced practitioner) desk. This will be required reading by all new chemists, engineers and analysts in my department." --Sean T. Nugent, Searle Research and Development "Practical Process Research & Development is just that, practical... Especially enjoyable are author Neal G. Anderson's pithy 'tips'... Fun chemistry throughout." --CHEMICAL INNOVATION. June 2000 "The new volume by Dr. Anderson ranks with the very best on the subject covering almost all aspects of process research and development and scale up in an informative and readable manner. ...the many "Tips" given throughout the book are practical and informative and should be mandatory reading for all synthetic organic chemists, including those in research and discovery. ...could well become a standard text on the subject. Indeed, it is my recommendation that Process Chemistry departments throughout the industry buy two copies, one for themselves and one to help educate their colleagues in research/discovery. Many of the topics covered and the tips given in the book could also be of great use to anyone organizing organic chemistry practical courses for students. Perhaps the highest praise one can give this book is to say that Foreword by Barry Sharpless raises very high expectations and the book meets and at times exceed those expectations." --ORGANIC PROCESS RESEARCH AND DEVELOPMENT, Vol.4, No.5, 2000 "Following enthusiastic Forwards by Barry Sharpless and Jerry Moniot, each chapter of the book addresses commonly encountered aspects of large-scale synthesis. Drawing extensively from literature case studies for illustration, Anderson also sprinkles useful tips throughout the text, while his use of lists, tables, and charts aids in reinforcing key concepts. The text readily succeeds as a highly practical tour throughout the considerations of chemical scale-up. Newly minted chemists will find this a valuable introductory text, while veteran researchers will also glean much from Anderson's extensive experience. The book can easily be recommended as a reading for a graduate organic synthesis course. Medicinal chemists may find this trove of practical synthetic know-how quite useful in their drug discovery programs. Certainly all readers will better appreciate the challenges faced by process chemists in bringing a compound through development and commercialization." --Christopher R. Schmid, Senior Research Scientist, Lilly Research Laboratories, Eli Lilly and Company, JOURNAL OF MEDICINAL CHEMISTRY, 2001, Vol. 44, No.7 "In summary, we believe that every newcomer to the exciting field of process research and development should read this book, but also experienced process chemists and even academics will find it very useful and stimulating. As the language of stock analysts and brokers is very popular today, we recommend Practical Process Research and Development, by Neal G. Anderson, as a "strong buy" because this investment will pay off very quickly." --ANGEWANDTE CHEMIE, 2001, 40, No. 7. "...Filled with valuable insights and personal experience.... Dr. Anderson's book is indeed the best text on process development available to organic chemists. I have bought several for my group." --ADVANCED SYNTHESIS AND CATALYSIS, 2001, Oljan Repic, Director of Process R&D, Novartis Institute for Biomedical Research
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Book Description
Foreword by K. Barry Sharpless, The Scripps Research Institute, La Jolla, CA and Dr. Jerome Moniot, Bristol-Myers Squibb
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Product details
Hardcover: 354 pages
Publisher: Academic Press; 1 edition (April 3, 2000)
Language: English
ISBN-10: 9780120594757
ISBN-13: 978-0120594757
ASIN: 0120594757
Product Dimensions:
6.1 x 0.9 x 9.2 inches
Shipping Weight: 1.1 pounds (View shipping rates and policies)
Average Customer Review:
5.0 out of 5 stars
6 customer reviews
Amazon Best Sellers Rank:
#1,726,393 in Books (See Top 100 in Books)
This is *the* book for process chemistry. I'm new to the field, but everyone I've talked to recommends this as the optimal starting point for learning about how process chemists think. Anderson does a great job of taking the reader through each concept while integrating TONS of examples so it's clear that this isn't just theory. I've heard that some of the things Anderson touts as rules are actually a little more fluid in industry, but this is of course dependent on what stage your project is at. For example, solvent choices aren't as strict as the book would make you believe, but he still does a great job of explaining why certain solvents are preferred and ways to move toward these preferred solvent systems.While this book frequently discusses concepts at quite a high level, it's still endlessly entertaining to read. Pages blow by very quickly. The only thing that has been a little strange is when the same chemical process is used in different chapters as an example of multiple different concepts. It's given me deja vu repeatedly, although each different example typically revolves around different data points.
Very GOOD!
I am an inorganic/organometallic chemist by training. I took a job as a research chemist at a small metals based specialty chemical manufacturing company. After a few years in the R&D lab I took a role as the head of scale-up for our new line of organic and organometallic materials. This role involves process development and scale-up of a wide variety of materials. This area is not something that was discussed much in graduate school (something I think should change). Because my company is small with a large ne'er of products, this is a continual learn-as-I-go experience. This book, along with McConville's The Pilot Plant Real Boom, have become my go to resources for any and all problems related to process development. Both would make excellent texts for a graduate level course on process chemistry.The examples are based on the author's experience in the pharmaceutical field. However, I feel that the information contained in the book may be used for any sort of process development, from organic to materials. It's been extremely useful for me.I would highly recommend this book for anyone in the process chemistry field, from graybeards (as a handy reference tool) to newly minted chemists (as a detailed protocol for process development).
Imagine you have many "old-timers" giving out practical tips each from years of experience. That is not often happening. This book does exactly that.It addresses process R&D in pharmaceutical and / or fine chemicals industry, taking one from laboratory bench to pilot or production scale. The differences and difficulties in scale-up were clearly demonstrated and the solutions provided. It educates and helps a R&D chemist or process chemist to ANTICIPATE, AVOID and OVERCOME the potential problems in process development and scale-up, at the START or EARLY stage of the project. Supported by many examples, the best practices and solutions are presented at the detailed technical level: routes, reagents, solvents, water, running and optimizing reactions, workup, chiral synthesis, etc.The author highlighted a lot of key advice in "boxes" and allows a quick one-hour read of the best points.
I read this book cover to cover, come back to it many times. No other process chemistry book teaches better than this one. Highly recommended.
If you ever wonder how to run your reaction on a three tons scale, this is one of the books to go for. On the top it is also real fun to read.
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